[Gnathostoma hispidum][Gnathostoma spinigerum]. Parasite Biology; Image Gallery; Laboratory Diagnosis; Treatment Information. Houve positividade de apenas uma das bandas (Kda) dos quatro peptídios imunogênicos testados para a larva terciária de Gnathostoma binucleatum. larva do nematódio Gnathostoma sp, que pode ocorrer no consumo de carne crua de peixes de água . cos da larva estágio A de Gnathostoma binucleatum.

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Gnathostoma malaysiae has also been implicated as causing human disease, but this is yet to be confirmed. Human gnathostomiasis is due to migrating immature worms. Adapted from a drawing provided by Dr.

In the natural definitive host pigs, cats, dogs, wild animals the adult worms reside in a tumor which they induce in the gastric wall. They deposit eggs that are unembryonated when passed in the feces.

Eggs become embryonated in water, and eggs release first-stage larvae. If ingested by a small crustacean Cyclops, first binucleattum hostthe first-stage larvae develop into second-stage larvae.

Following ingestion of the Cyclops by a fish, frog, or snake second intermediate hostthe second-stage larvae migrate into the flesh and develop into third-stage larvae. When the second intermediate host is ingested by a definitive host the third-stage larvae develop into adult parasites in the stomach wall.

Alternatively, the second intermediate host may be ingested by the paratenic host animals such as birds, snakes, and frogs in which gmathostoma third-stage larvae do not develop further but remain infective to the next predator.


Humans become infected by eating undercooked fish or poultry containing third-stage larvae, or reportedly by drinking water containing infective second-stage larvae binucletaum Cyclops. The clinical manifestations in human gnathostomiasis are caused by migration of the immature worms L3s. Migration in the subcutaneous tissues causes intermittent, migratory, painful, pruritic swellings cutaneous larva migrans.

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Migration to other tissues visceral larva migranscan result in cough, hematuria, and gnathosgoma involvement, with the most serious manifestations eosinophilic meningitis with myeloencephalitis. High eosinophilia is present. Note the presence of cuticular spines arrow. Note the multinucleate intestinal cells and the presence of pigmented granular material in the intestinal cells.

Morphologic diagnosis of human gnathostomiasis is made by the examination of larval worms in biopsy specimens. Currently there are no serologic tests available for gnathostomiasis at the CDC nor in the U. Please ynathostoma DPDx for the contact information for labs in Thailand and Japan that perform this test. Treatment information for gnathostomiasis can be found at: DPDx is an education resource designed for health professionals and laboratory scientists. For an overview including prevention and control visit www.

Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content. Enter Email Address What’s this? Recommend on Facebook Tweet Share Compartir. Life Cycle Adapted from a drawing provided by Dr. Image Gallery Head bulb and cuticular spines. Scanning electron micrographs of a Gnathostoma spinigerum female worm depicting binucleayum cuticular armature of the body surface. The cuticular biuncleatum is important for identification gnwthostoma Gnathostoma spp.


Cuticular spines of the posterior body part. Detail of cuticular spines of the anterior body part.

CDC – DPDx – Gnathostomiasis

Detail of nondendiculated cuticular spines. Cross-sections of Gnathostoma sp. Humans serve only as paratenic hosts for Gnathostoma spp. Identification of gnathostomiasis is achieved by serology or microscopic observation of the larval worms in tissue sections.

Diagnostic characters for Gnathostoma include the presence of large lateral chords, multinucleate intestinal cells some speciespresence of pigmented granular material in the intestinal cells, and the presence of spines on the cuticle, especially near the anterior end of the worm. Laboratory Diagnosis Laboratory Diagnosis Morphologic Diagnosis Morphologic diagnosis of human gnathostomiasis is made by the examination of larval worms in biopsy specimens.

Treatment Information Treatment Information Treatment information for gnathostomiasis can be found at: Get Email Updates To receive email updates about this page, enter your email address: December 13, Page last updated: December 13, Content source: Linking to a non-federal site does not constitute an endorsement by HHS, CDC or any of its employees of the sponsors or the information and products presented on the site.