Wiskott Aldrich syndrome (WAS) is a disease with immunological deficiency and reduced ability to form blood clots. Signs and symptoms include easy bruising. Wiskott-Aldrich syndrome (WAS) is an X-linked disorder characterized by the clinical triad of microthrombocytopenia, eczema, and recurrent. Request PDF on ResearchGate | Síndrome de Wiskott-Aldrich de un paciente diagnosticado en la infancia con enfermedad de Bruton.

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No geographical factor is present.

With epidermal involvement Eczematous contact dermatitis atopic dermatitis seborrheic dermatitis stasis dermatitis lichen simplex chronicus Darier’s disease glucagonoma syndrome langerhans cell histiocytosis lichen sclerosus pemphigus foliaceus Wiskott—Aldrich syndrome Zinc deficiency. D ICD – Alleles that produce no or truncated protein have more severe effects than missense mutations. Charcot—Marie—Tooth disease 2A Hereditary spastic paraplegia Treatment of Wiskott—Aldrich syndrome is currently based on correcting symptoms.

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Epidermolysis bullosa simplex with muscular dystrophy Epidermolysis bullosa simplex of Ogna plakophilin: Ornithine transcarbamylase deficiency Oculocerebrorenal syndrome Dyslipidemia: The diagnosis is made on the basis of clinical parameters, the peripheral blood smearand low immunoglobulin levels. Common variable immunodeficiency ICF syndrome. Clinical and Experimental Immunology. The estimated incidence of Wiskott—Aldrich syndrome in the United States is one inlive male births.


Freckles lentigo melasma endermedad melanoma.

Gestionan tratamiento en Italia de un niño tarijeño con síndrome de Wiskott-Aldrich

Alport syndrome Dent’s disease X-linked nephrogenic diabetes insipidus. The syndrome is named after Dr. Dyskeratosis congenita Hypohidrotic ectodermal dysplasia EDA X-linked ichthyosis X-linked endothelial corneal dystrophy.

Haemophilia A Haemophilia B X-linked sideroblastic anemia. Long QT syndrome 4.

Keratinopathy keratosiskeratodermahyperkeratosis: Wiskott—Aldrich syndrome has an X-linked recessive pattern of inheritance. WAS occurs most often in males due to its X-linked recessive pattern of inheritance, affecting between 1 and 10 males per million.

Tauopathy Cavernous venous malformation.

Wiskott–Aldrich syndrome

Journal of Leukocyte Biology. X-linked agammaglobulinemia Transient hypogammaglobulinemia of infancy.

Red Blanchable Erythema Generalized drug eruptions viral exanthems toxic erythema systemic lupus erythematosus. Purine nucleoside phosphorylase deficiency Hyper IgM syndrome 1. This article needs additional citations for verification. Skin fragility syndrome Arrhythmogenic right ventricular dysplasia 9 centrosome: The majority of children with WAS develop at least one autoimmune disorderand cancers mainly lymphoma and leukemia develop in up to a third of patients.

Anemia from bleeding may require iron supplementation or blood transfusion. Diseases of the skin and appendages by morphology.

Gestionan tratamiento en Italia de un niño tarijeño con síndrome de Wiskott-Aldrich

Recurrent bacterial infections develop by three months. The rare disorder X-linked neutropenia has also been linked to a specific subset of WAS mutations.


For severely low platelet counts, patients may require platelet transfusions or removal of the spleen. By using this site, you agree to the Terms of Use and Privacy Policy.

Wiskott–Aldrich syndrome – Wikipedia

Studies of correcting Wiskott—Aldrich syndrome with gene therapy using a lentivirus have begun. Aphthous stomatitis oral candidiasis lichen planus leukoplakia pemphigus vulgaris mucous membrane pemphigoid cicatricial pemphigoid herpesvirus coxsackievirus syphilis systemic histoplasmosis squamous-cell carcinoma.

Enlargement of the spleen is not uncommon. Views Read Edit View history. Epidermal wart callus seborrheic keratosis acrochordon molluscum contagiosum actinic keratosis squamous-cell carcinoma basal-cell carcinoma Merkel-cell carcinoma nevus sebaceous trichoepithelioma.

WAS patients have increased susceptibility to infections, particularly of the ears and sinuses, and this immune deficiency has been linked to decreased antibody production and the inability of immune T cells to effectively combat infection.

Often, leukemia may be suspected on the basis of low platelets and infections, and bone marrow biopsy may be performed. It contains amino acids and is mainly expressed in hematopoietic cells the cells in the bone marrow that develop into blood cells.