Carcinoma Mucoepidermoide de Glándulas Salivales Intraoral: Factores Clínicos y Patológicos e Inmunoexpresión de c-erbB-2 en 29 Casos. Vanessa Fátima. Publisher: El propósito de este estudio es presentar la casuística del carcinoma mucoepidermoide de glándulas salivales de pacientes diagnosticados en el. English: Tumors of the salivary glands represent % of head and neck neoplasms. Mucoepidermoid carcinoma (MEC) is the most common epithelial.

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Disease-free survival rates mucoepifermoide Due to the singularity and diverse histology of these tumors, prognostic factors have been difficult to elucidate. The clinicopathologic features and results of log rank tests for clinical variables are shown in tables 1 and 2respectively. Am J Surg Pathol.

High grade tumors, on the other hand, seem to arise more often in major salivary glands Kokemueller et al. Although the significance of this cytoplasmic staining remains unknown, Cheng et al. However, in the study of Lopes et gpandulas. Even though low-grade tumors did not develop metastases and high-grade glandulaa showed lower DFS rates after five years, no significant difference was found for the grading system or any of the evaluated prognostic factors.

Mucoepidermoid carcinoma of the salivary glands clinical review of 42 cases. Despite the small sample studied our results demonstrated no association among c-erbB-2 expression and demographic or histological grades of MEC.

Carcinoma mucoepidermoide de glándulas salivales en Brasil: relación clinicopatológica

All positive cases also expressed cytoplasmic staining. Low grade tumors seem to arise more often in minor salivary glands, which according to some authors are detected at earlier stages, probably due to the less aggressive growth in addition to a better visible tumor site.

Surgical Pathology ofthe salivary glands. For this study only the intraoral MEC surgically treated with adequate material for microscopic and immunohistochemical analysis corresponding to 29 cases were analyzed. Evaluation and application of grading criteria in cases.

Salivary gland tumors in children and adolescents: The biological features and clinical behavior of mucoepidermoid carcinomas are widely variable and poorly understood.


Jpn J Clin Oncol. Although the latter may present myoepitelial derivation, carcinoma ex pleomorphic adenoma probably adquired a particular biological behavior in the longstanding process of malignant transformation. Through a long follow-up period in present study we could highlight the relevance of primary anatomical site, tumor size and metastasis as useful prognostic factors that may affect survival in patients with a primary diagnosis of head and neck mucoepidermoid carcinomas.

Blocking of endogenous avidin-botin activity in immunohistochemistry.

Carcinoma mucoepidermoide

Data concerning survival recurrence and metastasis were evaluated. Muc4 and erbb2 expression in major and minor salivary gland mucoepidermoid carcinoma.

In our series, patients demonstrated an earlier average age of occurrence, with a peak of incidence in the third and fourth decades of life, whereas previous studies described a prevalence in fifth and sixth decades of life Auclair et al. The use of skim milk as an economical and effective substitute for commercial biotin solutions. Intraoral mucoepidermoid carcinoma of salivary glands. Complementary studies to compare carbohydrates of the normal salivary glands must be carried out because subtle alterations in tumor cells glycosylation can influence their biological behavior.

Future investigations could benefit from this study, helping to provide further strategies for more efficient management of MECs. Previous studies of c-erbB-2 expression in salivary gland carcinomas are sparse, comprise heterogeneous subtypes, and show contradictory results Locati et al.

Immunoexpression of c-erbB-2 and walivales in benign and malignant salivary neoplasms with myoepithelial differentiation. However, other studies reported a rare expression of c-erbB-2 on these tumors Kernohan et al. Mucoepidermoid carcinoma MEC is the most common malignant neoplasm of major and minor salivary glands Lopes et al, Its intracellular component has a tyrosine kinase activity, whereas the extracellular domain may act as a growth factor receptor because of its considerable homology with epidemial growth factor receptor Nguyen et al.

Selecting antibodies to detect HER2 overexpression by immunohistochemistry in invasive mammary carcinomas. Mucoepidermoid carcinoma of intraoral salivary glands. This abstract may be abridged.

Pattern of parotid gland tumors on Crete, Greece: Sinonasal and maxillary tumors were not included in the sample. Considering the results in the appraised sample, our findings suggest that some mucoepidermoid carcinoma overexpress c-erbB-2 independent of clinicopathological features such as patient age and gender and site or histological grades of the lesions.


The 5 and year overall survival rates were both In our series the salivalee were similar with 21 Casilla D Temuco – Chile Tel.: The follow-up period in this study ranged from 6 to months median 65 monthsmucoepiermoide the 5 and year OS rates were both However, users may print, download, or email articles for individual use.

The palate was the most commonly affected site, with 21 cases Immunohistochemical study of c-erbB-2 oncoprotein overexpression in human major salivary gland carcinoma: This provides further support to the existence of distinct molecular mechanisms in salivary gland carcinogenesis associated with the overexpression of c-erbB Unlike other studies that used this same grading system, 4,13 the results demonstrate a balance in distribution among the three tumor grades subtypes.

There darcinoma a wide variation in these malignant neoplasms mucodpidermoide different geographic areas and ethnic groups. MEC is reported to manifest variable biologic aggressiveness, basically showing correlation with its histological features and is carcinooma by a 3-tiered system Auclair et al, R; Dempsey, R J.

International histological classification of tumours. Remote access to EBSCO’s databases is permitted to patrons of subscribing institutions accessing from remote locations for personal, non-commercial use.

Studies on intra-oral MEC have shown similar results with a higher percentage of mycoepidermoide grade tumors Kokemueller et al. Through a long follow-up period in present study was highlight the relevance of primary anatomical site, tumor size and metastasis as useful prognostic factors that may affect survival in patients with a primary diagnosis of head and neck mucoepidermoid carcinomas.